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In contrast, under similar conditions, IL-6 treatment increased intracellular iron levels, decreased the expression of solute carrier family 40 member 1 (SLC40A1) and ferritin and yet without changing the GSH levels, and resulted in the sensitization of fibroblasts to ferroptosis ( Furthermore, a reduction in ferroptosis accompanied by a decrease in acyl coenzyme A synthetase long chain 4 (ACSL4) and increases in Gpx4, ferritin heavy chain 1 and SLC7A11 was observed in the synoviums and synovial fibroblasts from RA patients compared to those from healthy controls ( Ferroptosis and Inflammatory Bowel Diseases As the intestinal epithelium is a critical organ for nutrient absorption, cell death here must be carefully regulated, and any interference with cell regeneration or cell death processes may cause pathologies

137 In addition, adipose MSCs, hair follicle MSCs, and dental pulp MSCs reduce inflammatory responses, promote mucosal healing, and improve intestinal barrier function

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Additional confirmational assays, such as Western blotting, are required to confirm the expression level of proteins such as BCL-2, TLR4, and other inflammatory mediators